A Ce-MOF@polydopamine composite nanozyme as an efficient scavenger for reactive oxygen species and iron in thalassemia disease therapy
Yan Duan, Ling Liang, Fanggui Ye, Shulin Zhao
Abstract
. Furthermore, the serum ferritin levels and iron concentrations in the liver of IO mice were reduced following treatment with Ce-MOF@PDA, and the fecal clearance ability was comparable to that of deferoxamine. These results indicate that Ce-MOF@PDA can eliminate IO while scavenging ROS and reduce tissue damage caused by oxidative stress. Therefore, the Ce-MOF@PDA nanozyme is a promising therapeutic nanomedicine for treating thalassemia IO.
Topics & Concepts
Reactive oxygen speciesOxidative stressChemistryCatalaseSuperoxide dismutaseFerritinDeferoxamineThalassemiaDopaminePharmacologyBiochemistryMedicineInternal medicineAdvanced Nanomaterials in CatalysisHemoglobinopathies and Related DisordersPharmacological Effects and Toxicity Studies