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In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target

Xiaoqing Wang, Collin Tokheim, Shengqing Gu, Binbin Wang, Qin Tang, Yihao Li, Nicole Traugh, Zexian Zeng, Yi Zhang, Ziyi Li, Boning Zhang, Jingxin Fu, Tengfei Xiao, Wei Li, Clifford A. Meyer, Jun Chu, Peng Jiang, Paloma Cejas, Klothilda Lim, Henry W. Long, Myles Brown, X. Shirley Liu

2021Cell198 citationsDOIOpen Access PDF

Topics & Concepts

BiologyCRISPRCancer immunotherapyUbiquitin ligaseIn vivoCancer researchGenome editingImmunotherapyCell biologyComputational biologyCancerGeneticsUbiquitinGeneProtein Degradation and InhibitorsHIV Research and TreatmentCAR-T cell therapy research
In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target | Litcius