The Marine Natural Product Manzamine A Inhibits Cervical Cancer by Targeting the SIX1 Protein
Dev Karan, Seema Dubey, Lucia Pirisi, Alexis Nagel, Ivett Piña, Yeun‐Mun Choo, Mark T. Hamann
Abstract
) class with potential antiproliferative activity, molecular networking facilitated the efficient identification, dereplication, and assignment of structures from the manzamine class and revealed the significant potential in the design of optimized molecules for the treatment of cervical cancer. These data suggest that this sponge-derived natural product class warrants further attention regarding the design and development of novel manzamine analogues, which may be efficacious for preventive and therapeutic treatment of cancer. Additionally, this study reveals the significance of protecting fragile marine ecosystems from climate change-induced loss of species diversity.