Insights into Polyprotein Processing and RNA-Protein Interactions in Foot-and-Mouth Disease Virus Genome Replication
Danielle M. Pierce, Connor Hayward, David J. Rowlands, Nicola J. Stonehouse, Morgan R. Herod
Abstract
alternative pathways (i.e., intra- and intermolecular proteolysis). The role of alternative processing pathways may help coordination of viral replication by providing temporal control of protein production and here we analyze the consequences of amino acid substitutions that change these pathways in FMDV. Our data suggest that correct processing is required to produce key enzymes for replication in an environment in which they can interact with essential viral RNA elements. These data further the understanding of RNA genome replication.
Topics & Concepts
BiologyFoot-and-mouth disease virusVirologyVirusDiseaseGenomeViral replicationRNAFoot-and-mouth diseaseAphthovirusReplication (statistics)GeneticsGenePathologyMedicineAnimal Disease Management and EpidemiologyViral Infections and Immunology ResearchVector-Borne Animal Diseases