Chemical constituents from the aerial parts of <i>Rubia cordifolia</i> L. with their NO inhibitory activity
Hong Zhang, Wen-Tao Fang, Yan Li, Qinghua Kong, Fang Cheng-wu, Han Luo, Shou‐Jin Liu
Abstract
A new naphthoquinone derivative (1) together with twenty-three known compounds (2–24), were isolated from the aerial parts of Rubia cordifolia L. Their structures were elucidated on the basis of NMR and HR-ESIMS data. Compounds 1–13 were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 2-6 exhibited significant inhibitory activities with IC50 values of 21.37, 13.81, 24.56, 20.32, and 30.08 μmol·L−1, respectively.
Topics & Concepts
ChemistryInhibitory postsynaptic potentialDerivative (finance)StereochemistryIC50AnthraquinonesNaphthoquinoneTwo-dimensional nuclear magnetic resonance spectroscopyOrganic chemistryBiochemistryBotanyBiologyIn vitroFinancial economicsEconomicsNeuroscienceMorinda citrifolia extract usesBioactive Compounds and Antitumor AgentsPharmacological Effects of Natural Compounds