Discovery of higenamine as a potent, selective and cellular active natural LSD1 inhibitor for MLL-rearranged leukemia therapy
Yuan Fang, Chao Yang, Dehong Teng, Shiwei Su, Xiang Luo, Zhongqiu Liu, Guochao Liao
Topics & Concepts
ChemistryLeukemiaEpigeneticsK562 cellsApoptosisCD86Cancer researchBiochemistryBiologyGeneImmunologyPhenotypeEpigenetics and DNA MethylationHistone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics