Tissue resident memory T cells are enriched and dysfunctional in effusion of patients with malignant tumor
Xueying Mao, Yue Chen, Xiulian Lu, Shuiping Jin, Piao Jiang, Zhangfeng Deng, Xiaoyun Zhu, Qichun Cai, Changyou Wu, Shuangpeng Kang
Abstract
Our study is the first to identify the presence of Trm cells in malignant effusion and will lay the foundation for future research on anti-tumor immunity of Trm cells in malignant effusion.
Topics & Concepts
MedicinePleural effusionMalignant pleural effusionCytotoxic T cellCD8EffusionAscitesPathologyImmune systemFlow cytometryCancer researchImmunologyInternal medicineBiologyIn vitroSurgeryBiochemistryCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionCAR-T cell therapy research