Optimal targeting of PI3K-AKT and mTOR in advanced oestrogen receptor-positive breast cancer
Iseult Browne, Fabrice André, Sarat Chandarlapaty, Lisa A. Carey, Nicholas C. Turner
Topics & Concepts
PTENPI3K/AKT/mTOR pathwayEverolimusBreast cancerCancer researchMedicineCancerProtein kinase BAKT1Discovery and development of mTOR inhibitorsOestrogen receptorOncologyBioinformaticsInternal medicineSignal transductionBiologyBiochemistryAdvanced Breast Cancer TherapiesPI3K/AKT/mTOR signaling in cancerCancer Treatment and Pharmacology