Bioreducible and pH-responsive shell crosslinked polymeric micelles from a star-shaped terpolymer as drug delivery system
Sanaz Motamedi, Bakhshali Massoumi, Mehdi Jaymand, Hossein Derakhshankhah, Effat Alizadeh
Abstract
Novel shell crosslinked (SCL) pH- and reduction-responsive micelles were fabricated through the grafting of DMAEMA and AA monomers onto a star-shaped PCL through ATRP followed by crosslinking with Cys. The chemical structures of the samples were investigated using 1H NMR and FTIR. The developed micelles were loaded with MTX as an anticancer drug and their drug loading and encapsulation efficiencies were calculated to be 31.53 ± 0.3% for both. The fabricated drug delivery system (DDS) exhibited slow and stimuli-triggered drug release behavior. The anticancer performance of the DDS was examined using MTT assay against MCF7 cells.
Topics & Concepts
MicelleCopolymerDrug deliveryMonomerMaterials scienceGraftingFourier transform infrared spectroscopyPolymer chemistryChemical engineeringNuclear chemistryChemistryNanotechnologyOrganic chemistryPolymerComposite materialAqueous solutionEngineeringNanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and CharacterizationPolymer Surface Interaction Studies