Aqueous ZnCl<sub>2</sub> Complex Catalyzed Prins Reaction of Silyl Glyoxylates: Access to Functionalized Tertiary α-Silyl Alcohols
Man‐Yi Han, Hong Pan, Pinhua Li, Lei Wang
Abstract
An efficient Prins reaction of silyl glyoxylates in the presence of an aqueous ZnCl2 complex as a catalyst was developed, providing functionalized tertiary α-silyl alcohols in high yields under mild conditions. A preliminary investigation indicated that the aqueous ZnCl2 complex acted as a dual functional catalyst of Brønsted and Lewis acid to activate the carbonyl groups of silyl glyoxylates via a dual-activation model.
Topics & Concepts
SilylationChemistryCatalysisAqueous solutionLewis acids and basesOrganic chemistryPrins reactionMedicinal chemistrySynthetic Organic Chemistry MethodsAsymmetric Synthesis and CatalysisChemical Synthesis and Reactions