Anti-quorum sensing and antibiofilm activity of coumarin derivatives against <i>Pseudomonas aeruginosa</i> PAO1: Insights from <i>in vitro</i> and <i>in silico</i> studies.
Amineh Sadat Tajani, Zeinab Amiri‐Tehranizadeh, Arianoosh Pourmohammad, Armin Pourmohammad, Milad Iranshahi, Faegheh Farhadi, Vahid Soheili, Bibi Sedigheh Fazly Bazzaz
Abstract
Objectives: Biofilm-associated infections are challenging to manage or treat since the biofilm matrix is impenetrable to most antibiotics. Therefore, the best approach to deal with biofilm infections is to interrupt the construction during the initial levels. Biofilm formation has been regulated through the quorum sensing (QS) network, making it an attractive target for any antibacterial therapy. Materials and Methods: PAO1 were evaluated. Results: gene expression. Conclusion: The biofilm formation test, virulence factors production assays, gene expression analysis, and molecular dynamic simulations data demonstrated that coumarin derivatives are a potential anti-QS family through PqsR inhibition.