A S100A14-CCL2/CXCL5 signaling axis drives breast cancer metastasis
Xukun Li, Minjie Wang, Tongyang Gong, Xuemeng Lei, Ting Hu, Maoqing Tian, Fang Ding, Fei Ma, Hongyan Chen, Zhihua Liu
Abstract
: S100A14 is significantly upregulated in breast cancer, it can promote breast cancer metastasis by increasing the expression and secretion of CCL2/CXCL5 via RAGE-NF-κB pathway. And S100A14 has the potential to serve as a serological marker for diagnosis of breast cancer. Collectively, we identify S100A14 as an upstream regulator of CCL2/CXCL5 signaling and a metastatic driver of breast cancer.
Topics & Concepts
CXCL5MetastasisBreast cancerCancer researchCancerBreast cancer metastasisCCL2MedicineSignal transductionInternal medicineOncologyBiologyCancer metastasisChemokineCell biologyInflammationS100 Proteins and AnnexinsChemokine receptors and signalingImmune Response and Inflammation