Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C
Jianli Tang, Sahibzada Waheed Abdullah, Pinghua Li, Jin’en Wu, Chenchen Pei, Suyu Mu, Yunlu Wang, Shiqi Sun, Huichen Guo
Abstract
FMDV is the leading cause of the foot-and-mouth disease (FMD), affecting cloven-hoofed animals with high morbidity and mortality. We determined that HSP60 is required for efficient viral RNA replication and mRNA translation during FMDV infection.
Topics & Concepts
Viral replicationBiologyHSP60VirologyVirusFoot-and-mouth disease virusViral life cycleHeat shock proteinTranslation (biology)RNACell biologyMessenger RNAGeneticsGeneHsp70Animal Disease Management and EpidemiologyViral Infections and Immunology ResearchVector-Borne Animal Diseases