EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity
Ran Jing, Irene Scarfò, Mohamad Najia, Edroaldo Lummertz da Rocha, Areum Han, Michael Sanborn, Trevor Bingham, Caroline Kubaczka, Deepak K. Jha, Marcelo Falchetti, Thorsten M. Schlaeger, Trista E. North, Marcela V. Maus, George Q. Daley
Topics & Concepts
BiologyInduced pluripotent stem cellCell biologyReprogrammingCellular differentiationT-cell receptorEmbryonic stem cellJurkat cellsPsychological repressionT cellCellImmunologyGeneticsGene expressionImmune systemGeneCAR-T cell therapy researchCRISPR and Genetic EngineeringImmune Cell Function and Interaction