Upregulation of CXCL1 and LY9 contributes to BRCAness in ovarian cancer and mediates response to PARPi and immune checkpoint blockade
Tingting Chen, Tong Yu, Shuping Zhuang, Yiding Geng, Junwen Xue, Jiayi Wang, Liqiang Ai, Bo Chen, Zhangxiang Zhao, Yawei Li, Jinghao Wang, Haihai Liang, Yan Xu, Yunyan Gu
Topics & Concepts
Downregulation and upregulationImmune checkpointBlockadeCXCL1Immune systemImmunologyCancer researchMedicineBiologyImmunotherapyInternal medicineChemokineReceptorGeneticsGenePARP inhibition in cancer therapyBRCA gene mutations in cancerFerroptosis and cancer prognosis