Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II
Ruben G.G. Leenders, Shoshy Alam Brinch, Sven T. Sowa, Enya Amundsen-Isaksen, Albert Galera‐Prat, Sudarshan Murthy, Sjoerd Aertssen, Johannes N. Smits, Piotr Nieczypor, Eddy Damen, Anita Wegert, Marc Nazaré, L. Lehtiö, Jo Waaler, Stefan Krauß
Abstract
induced dose-dependent biomarker engagement and reduced cell growth in the colon cancer cell line COLO 320DM.
Topics & Concepts
ADMEChemistryWnt signaling pathwayLead compoundIC50PharmacokineticsPharmacologySignal transductionBiochemistryCancer researchIn vitroBiologyWnt/β-catenin signaling in development and cancerCoagulation, Bradykinin, Polyphosphates, and AngioedemaCancer-related gene regulation