A Unique and Stable Polyproline I Helix Sorted out from Conformational Equilibrium by Solvent Polarity
Matteo Pollastrini, Luca Pasquinelli, Marcin Górecki, Federica Balzano, Lorenzo Cupellini, Filippo Lipparini, Gloria Uccello‐Barretta, Fabio Marchetti, Gennaro Pescitelli, Gaetano Angelici
Abstract
amide isomer, when dissolved in polar solvents. The cooperative effect of only four amino acidic units is sufficient to form a preferential structure in solution. We shed light on this rare secondary structure with a thorough analysis of the spectroscopic and chiroptical properties of the tetramer, supported by X-ray crystallography and computational studies.
Topics & Concepts
Polyproline helixChemistryHelix (gastropod)TetramerSolvent polarityCrystallographySolventHydrogen bondAmideStereochemistryPeptideMoleculeOrganic chemistryBiologyBiochemistrySnailEcologyEnzymeChemical Synthesis and AnalysisProtein Structure and DynamicsDNA and Nucleic Acid Chemistry