Xanthine oxidoreductase activity in marathon runners: potential implications for marathon-induced acute kidney injury
Keisei Kosaki, Shota Kumamoto, Katsuyuki Tokinoya, Yukiko Yoshida, Takeshi Sugaya, Takayo Murase, Seigo Akari, Takashi Nakamura, Yoshiharu Nabekura, Kazuhiro Takekoshi, Seiji Maeda
Abstract
This study is the first to show marathon running transiently increases plasma XOR activity and levels of purine degradation products (hypoxanthine, xanthine, and uric acid), and further to demonstrate that activated plasma XOR may contribute to marathon-induced elevations in biomarkers of AKI. These findings significantly extend our prior knowledge of the purine metabolic pathway and several AKI biomarkers under strenuous exercise conditions.
Topics & Concepts
Uric acidCreatinineXanthineHypoxanthineInternal medicineUrinary systemPurineAcute kidney injuryKidneyChemistryEndocrinologyUrineXanthine oxidaseMedicineBiochemistryEnzymeGout, Hyperuricemia, Uric AcidHigh Altitude and HypoxiaMuscle metabolism and nutrition