Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice
Qingqing Li, Xiao Wang, Zhao Hua Wang, Zhenzong Lin, Jieyi Yang, Jichun Chen, Rui Wang, Wenfeng Ye, Ya Li, Yingying Wu, Aiguo Xuan
Abstract
-JAK2, P-STAT3, SYN, and PSD-95 also increased. Therefore, this study demonstrates that BCG immunization in APP/PS1 mice mitigated hippocampal dendritic spine pathology, especially after the third round of immunization. This effect could possibly be attributed to; changes in dendritic arborization and spine morphology or increases in SYN and PSD-95 expression levels. It could also be related to mechanisms of BCG-induced increases in IFN-γ or IL-4/JAK2/STAT3 levels.
Topics & Concepts
Dendritic spineImmunizationDendritic cellImmunologyImmune systemVaccinationHippocampal formationDendritic filopodiaBiologyMedicineNeuroscienceImmune responses and vaccinationsImmune Response and InflammationNeuroinflammation and Neurodegeneration Mechanisms