Lycopene from tomatoes and tomato products exerts renoprotective effects by ameliorating oxidative stress, apoptosis, pyroptosis, fibrosis, and inflammatory injury in calcium oxalate nephrolithiasis: the underlying mechanisms
Xiaomin Gao, Xiaomin Gao, Binwei Lin, Chen Chen, Ziyu Fang, Jinzhao Yang, Shuzhi Wu, Qing Chen, Kewen Zheng, Zhixian Yu, Yeping Li, Xiaofeng Gao, Xiaofeng Gao, Guanyang Lin, Lianguo Chen
Abstract
Several mechanisms underlying nephrolithiasis, one of the most common urological diseases, involve calcium oxalate formation, including oxidative stress, inflammatory reactions, fibrosis, pyroptosis, and apoptosis.
Topics & Concepts
LycopeneOxidative stressPyroptosisChemistryCalcium oxalatePharmacologyReactive oxygen speciesProtein kinase BApoptosisAntioxidantBiochemistryProgrammed cell deathMedicineUrineKidney Stones and Urolithiasis TreatmentsDialysis and Renal Disease ManagementSelenium in Biological Systems