Biofunctionalization of zirconia with cell-adhesion peptides <i>via</i> polydopamine crosslinking for soft tissue engineering: effects on the biological behaviors of human gingival fibroblasts and oral bacteria
Zhen Yang, Mingyue Liu, Yang Yang, Miao Zheng, Yang Yang, Xiaoqiang Liu, Jianguo Tan
Abstract
, and bacterial adhesion was evaluated by scanning electron microscopy and live/dead staining. PDA and PDA-RGD coatings decreased zirconia surface colonization by both bacterial species to similar extents. Thus, PDA-RGD-functionalized zirconia modulates specific HGF responses, while maintaining the antimicrobial activity of the PDA coating. The selective bio-interaction pattern of this surface modification holds great promise for improving soft-tissue integration around zirconia abutments in clinical applications.
Topics & Concepts
AdhesionTissue engineeringMaterials scienceCell adhesionCubic zirconiaBiomedical engineeringHard tissueNanotechnologyBiophysicsPolymer chemistryComposite materialDentistryMedicineBiologyCeramicPolymer Surface Interaction StudiesElectrospun Nanofibers in Biomedical ApplicationsBone Tissue Engineering Materials