Small-molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance
Ting Song, Yafei Guo, Zuguang Xue, Zongwei Guo, Ziqian Wang, Donghai Lin, Hong Zhang, Hao Pan, Xiaodong Zhang, Fangkui Yin, Hang Wang, Laura B. Uwituze, Zhichao Zhang
Topics & Concepts
K562 cellsCancer researchHsp70breakpoint cluster regionBiologyApoptosisChemistryReceptorHeat shock proteinBiochemistryGeneChronic Myeloid Leukemia TreatmentsResearch on Leishmaniasis StudiesInsect Resistance and Genetics