Copper-catalyzed [4+2] oxidative annulation of α,β-unsaturated ketoxime acetates with ethyl trifluoropyruvate
Huan Yan, Gaochen Xu, Meng Gu, Sai Zhang, Qinghuan Wu, Jingjing Meng, Ning Zhu, Zheng Fang, Jindian Duan, Kai Guo
Abstract
The copper-catalyzed [4+2] oxidative annulation of α,β-unsaturated ketoxime acetates with ethyl trifluoropyruvate for the synthesis of 2 H -1,3-oxazines is described.
Topics & Concepts
AnnulationChemistryOxazinesOximeOxidative phosphorylationTrifluoromethylCatalysisCopperOrganic chemistryMedicinal chemistryBiochemistryAlkylCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis and Biological Evaluation