Sesquiterpenes from<i>Rhododendron nivale</i>and Their Anti‐Inflammatory Activity
Xi Zeng, Wei Liu, Tao Yuan
Abstract
Abstract Two new germacrane sesquiterpenes, named nivalenoids A and B ( 1 and 2 ), along with four known sesquiterpenes ( 3 – 6 ), were isolated from the Rhododendron nivale . The structures of compounds 1 and 2 were elucidated by integrating spectroscopic analyses, including NMR, UV, IR, as well as HR‐MS data. Anti‐inflammatory activity by inhibiting lipopolysaccharide (LPS)‐induced NO production in RAW 264.7 cells revealed that compared with the positive control dexamethasone (IC 50 =2.50 μM), compounds 1 and 2 showed mild anti‐inflammatory activity, with IC 50 value of 27.55 μM and 53.26 μM, respectively.
Topics & Concepts
ChemistryIC50Anti-inflammatoryLipopolysaccharidePositive controlDexamethasoneTerpeneSesquiterpeneStereochemistryTraditional medicineIn vitroBiochemistryPharmacologyBiologyEndocrinologyMedicineEssential Oils and Antimicrobial ActivityBioactive Natural Diterpenoids ResearchNatural product bioactivities and synthesis