Dual role of BrCF<sub>2</sub>CO<sub>2</sub>Et: difluorocarbene-enabled access to α-trifluoromethyl ketones from sulfoxonium ylides
Chun‐Yan Wu, Xiang‐Long Chen, Huai‐Yu Wang, Dongsheng Yang, Shi‐Yi Zhuang, You Zhou, Zhi‐Cheng Yu, Yan‐Dong Wu, Xiao Geng, An‐Xin Wu
Abstract
A transition metal and external fluorine anion-free method has been developed for the efficient trifluoromethylation of sulfoxonium ylides with BrCF 2 CO 2 Et to afford α-trifluoromethyl ketones.
Topics & Concepts
DifluorocarbeneTrifluoromethylationChemistryTrifluoromethylTransition metalOrganic chemistryCombinatorial chemistryCatalysisAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsInorganic Fluorides and Related Compounds