Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a
Meiqian Xu, Xiao‐Dong Su, Xian Xiao, Hongliang Yu, Xiaoxia Li, Armand Keating, Shihua Wang, Robert Chunhua Zhao
Abstract
alters the pro-angiogenic ability of exosomes by modulating the expression of exosomal miRNAs, especially miR-146a, thus providing new insights into the correlation between parental cell state and exosome content and function.
Topics & Concepts
Mesenchymal stem cellMicrovesiclesHydrogen peroxideSenescenceWound healingMedicineStem cellCellCell biologyCancer researchmicroRNAChemistryImmunologyPathologyBiologyBiochemistryInternal medicineGeneExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases