Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1
Sebastian Dieckmann, Akim Strohmeyer, Monja Willershäuser, Stefanie Maurer, Wolfgang Wurst, Susan Marschall, Martin Hrabě de Angelis, Ralf Kühn, Anna Worthmann, Marceline M. Fuh, Jöerg Heeren, Nikolai Köhler, Josch K. Pauling, Martin Klingenspor
Abstract
We provide evidence that the abundance of UCP1 does not influence energy metabolism at thermoneutrality studying a novel Cre-mediated UCP1-KO mouse model. This model will be a foundation for a better understanding of the contribution of UCP1 in different cell types or life stages to energy metabolism.
Topics & Concepts
ThermogeninThermogenesisBrown adipose tissueKnockout mouseEndocrinologyInternal medicineAdipose tissueBiologyObesityMedicineReceptorAdipose Tissue and MetabolismMuscle metabolism and nutritionDiet and metabolism studies