Generation of zwitterionic trifluoromethyl <i>N</i>-allylic ylides and their use in switchable divergent annulations
Ru‐Jie Yan, Baoxin Liu, Yuan Hu, Wei Du, Ying‐Chun Chen
Abstract
catalyst or substrate control. A diverse range of frameworks, having a trifluoromethylated all-carbon quaternary stereogenic centre or a tetrasubstituted alkene moiety, are generally constructed in good yields with excellent enantioselectivity.
Topics & Concepts
Allylic rearrangementTrifluoromethylChemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsAsymmetric Synthesis and Catalysis