Low expression of miR-138 inhibit the proliferation, migration and invasion of colorectal cancer and affect patient survival by targeting SIRT1
Xianwu Kang, Bin Kong, Qiang Chen, Shipeng Zhao
Abstract
BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers in the world, resulting in about 600,000 deaths every year. It is urgent to explore the molecular mechanism and find new effective therapy. Abnormal molecular expression in cancer is considered as a screening biomarker and therapeutic target for tumors, MicroRNA (miRNA) as one of the important molecules, plays an important role in the regulation of tumorigenesis. METHODS: were studied by Transwell assay. RESULTS: . CONCLUSIONS: Thus, we found that miR-138 could inhibit CRC cell proliferation, migration and invasion by targeting SIRT1 firstly, and that will provide a new idea for the therapy of CRC.
Topics & Concepts
Colorectal cancerGene knockdownCancer researchmicroRNAMetastasisCarcinogenesisCancerBiomarkerCell growthBiologyMedicineOncologyCell cultureInternal medicineGeneGeneticsMicroRNA in disease regulationSirtuins and Resveratrol in MedicineCircular RNAs in diseases