Oxyanion transport across lipid bilayers: direct measurements in large and giant unilamellar vesicles
Krzysztof M. Bąk, Bartjan van Kolck, Krystyna Maslowska-Jarzyna, Panagiota Papadopoulou, Alexander Kros, Michał J. Chmielewski
Abstract
A simple di(thioamido)carbazole 1 serves as a potent multispecific transporter for various biologically relevant oxyanions, such as drugs, metabolites and model organic phosphate. The transport kinetics of a wide range of oxyanions can be easily quantified by a modified lucigenin assay in both large and giant unilamellar vesicles.
Topics & Concepts
VesicleChemistryOxyanionCarbazoleLipid bilayerKineticsBiophysicsMembraneBiochemistryOrganic chemistryBiologyPhysicsCatalysisQuantum mechanicsMolecular Sensors and Ion DetectionLipid Membrane Structure and BehaviorDrug Transport and Resistance Mechanisms