Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology
Nayara Braga Emídio, Brandi M. Small, Amanda R. Keller, Ross W. Cheloha, Laura M. Wingler
Topics & Concepts
Allosteric regulationPharmacophoreChemistryAllosteric modulatorAgonistG protein-coupled receptorReceptorAngiotensin IILigand (biochemistry)RadioligandPartial agonistStereochemistryBiochemistryMonoclonal and Polyclonal Antibodies ResearchReceptor Mechanisms and SignalingNeuropeptides and Animal Physiology