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A small-molecule activation mechanism that directly opens the KCNQ2 channel

Shao-ying Zhang, Demin Ma, Kun Wang, Ya Li, Zhenni Yang, Xiaoxiao Li, Junnan Li, Jiangnan He, Lianghe Mei, Yangliang Ye, Zongsheng Chen, Juwen Shen, Panpan Hou, Jiangtao Guo, Qiansen Zhang, Huaiyu Yang

2024Nature Chemical Biology36 citationsDOI

Topics & Concepts

GatingPotassium channelIon channelChemistryActivator (genetics)Voltage-gated ion channelConductanceMechanism (biology)BiophysicsDrug discoverySmall moleculeVoltage-gated potassium channelNanotechnologyMaterials scienceBiochemistryBiologyPhysicsGeneReceptorCondensed matter physicsQuantum mechanicsIon channel regulation and functionCardiac electrophysiology and arrhythmiasElectrochemical Analysis and Applications
A small-molecule activation mechanism that directly opens the KCNQ2 channel | Litcius