Quantifying the effect of PEG architecture on nanoparticle ligand availability using DNA-PAINT
Teodora Andrian, Sílvia Pujals, Lorenzo Albertazzi
Abstract
-glycolide)-poly(ethylene glycol) (PLGA-PEG) NPs with different PEG structures. We demonstrated how the length of the PEG spacer can influence the accessibility of surface chemical functionality, highlighting the importance of SRM techniques to support the rational design of functionalized NPs.
Topics & Concepts
PEG ratioNanoparticleEthylene glycolRational designNanotechnologyMaterials scienceNanoscopic scaleSurface modificationLigand (biochemistry)Colloidal goldDNAPLGAResolution (logic)Chemical engineeringChemistryComputer scienceEngineeringBiochemistryReceptorEconomicsArtificial intelligenceFinanceNanoparticle-Based Drug DeliveryNear-Field Optical MicroscopyAdvanced Fluorescence Microscopy Techniques