Green Chromatographic Method for Determination of Active Pharmaceutical Ingredient, Preservative, and Antioxidant in an Injectable Formulation: Robustness by Design Expert
Leela Prasad Kowtharapu, Naresh Kumar Katari, Christian A. Sandoval, Vijay Kumar Rekulapally, Sreekantha B. Jonnalagadda
Abstract
) values were obtained as >0.999 for the three components. Analytical solutions are stable for 48 h at benchtop and refrigerator conditions. The greenness of the analytical method was evaluated by the Green Analytical Procedure Index (GAPI), National Environmental Method Index (NEMI), analytical eco-scale, and Analytical Greenness (AGREE) tools to confirm that the method is eco-friendly.
Topics & Concepts
ChromatographyPreservativeChemistryRepeatabilityRelative standard deviationDetection limitFood scienceAnalytical Chemistry and ChromatographyAnalytical Methods in PharmaceuticalsAntibiotics Pharmacokinetics and Efficacy