Rhodium‐Catalyzed Atroposelective Construction of Indoles via C−H Bond Activation
Lincong Sun, Haohua Chen, Bingxian Liu, Junbiao Chang, Lingheng Kong, Fen Wang, Yu Lan, Xingwei Li
Abstract
Abstract Reported herein is the rhodium(III)‐catalyzed C−H activation of anilines bearing an N ‐isoquinolyl directing group for oxidative [3+2] annulation with four classes of internal alkynes, leading to atroposelective indole synthesis via dynamic kinetic annulation with C‐N reductive elimination constituting the stereo‐determining step. This reaction proceeds under mild conditions with high regio‐ and enantioselectivity and functional group compatibility.
Topics & Concepts
RhodiumAnnulationChemistryIndole testCatalysisFunctional groupMedicinal chemistryOxidative phosphorylationCombinatorial chemistryStereochemistryOrganic chemistryPolymerBiochemistryAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization MethodsAlkaloids: synthesis and pharmacology