Association of Lipoprotein(a) With Severe Degenerative Aortic Valve Stenosis
Ah‐Ram Kim, Jung-Min Ahn, Do‐Yoon Kang, Tae Joon Jun, Byung Joo Sun, Ho Jin Kim, Joon Bum Kim, Dae‐Hee Kim, Duk‐Woo Park, Young‐Hak Kim, Ki Hoon Han, Seung‐Jung Park
Abstract
Background: Lipoprotein(a) (Lp[a]) is associated with the development of aortic valve calcification. Objectives: The aim of this study was to evaluate the association between the serum level of Lp(a) and the development of severe degenerative aortic stenosis (AS) and subsequent aortic valve replacement (AVR). Methods: A total of 44,742 patients with Lp(a) measurements and echocardiography at baseline evaluation between 2000 and 2020 were included from a single tertiary heart center. The primary outcome was the development of severe degenerative AS, defined as a transaortic maximal velocity of ≥4.0 m/s. Results: = 0.96) AS. Conclusions: Lp(a) levels >100 mg/dL were significantly associated with risk for severe degenerative AS and subsequent AVR, regardless of the baseline severity of AS. Such associations were not observed in other etiologies of severe AS.