Cocrystallization of axitinib with carboxylic acids: preparation, crystal structures and dissolution behavior
Bo-Ying Ren, Xia-Lin Dai, Jie Wang, Chao Wu, Tong‐Bu Lu, Jia‐Mei Chen
Abstract
Three cocrystals of axitinib were prepared, and they demonstrated a significantly improved apparent solubility and dissolution rate without compromising physical stability.
Topics & Concepts
AxitinibDissolutionCarboxylic acidChemistryMaterials scienceOrganic chemistryMedicineSorafenibCancer researchHepatocellular carcinomaCrystallography and molecular interactionsCrystal structures of chemical compoundsCrystallization and Solubility Studies