Electrochemiluminescent Chiral Discrimination with a Pillar[5]arene Molecular Universal Joint-Coordinated Ruthenium Complex
Chunhong Liu, Jiabin Yao, Chao Xiao, Ting Zhao, Narayanan Selvapalam, Cuisong Zhou, Wanhua Wu, Cheng Yang
Abstract
A bicyclic pillar[5]arene derivative fused with a bipyridine side ring, a so-called molecular universal joint (MUJ), was synthesized, and the pair of enantiomers was resolved by high-performance liquid chromatography enantioresolution. The electrochemiluminescent detection based on the ruthenium complex of the enantiopure MUJ showed excellent chiral discrimination toward certain amino acids.
Topics & Concepts
Enantiopure drugRutheniumChemistryPillarEnantiomerDerivative (finance)Combinatorial chemistryMoleculeBipyridineBicyclic moleculeStereochemistryEnantioselective synthesisOrganic chemistryCrystal structureCatalysisFinancial economicsStructural engineeringEconomicsEngineeringMolecular Sensors and Ion DetectionSupramolecular Chemistry and ComplexesMetal-Organic Frameworks: Synthesis and Applications