One-step light-up metabolic probes for <i>in situ</i> discrimination and killing of intracellular bacteria
Eric Y. Yu, Michelle M. S. Lee, Joe H. C. Chau, Kristy W. K. Lam, Hojeong Park, Ryan T. K. Kwok, Jacky W. Y. Lam, Yuanyuan Li, Ben Zhong Tang
Abstract
TPEPy-Ala and TPAPy-Kdo with metabolic moieties can be directly incorporated into the bacterial cell envelopes and light up intracellular bacteria. Additionally, the metabolic probes can effectively eliminate labeled bacteria in situ with minimal host cell cytotoxicity via photodyanmic therapy.
Topics & Concepts
BacteriaIntracellularIn situIntracellular parasiteBacterial cell structureMetabolic activityChemistryCytotoxicityBiochemistryBiophysicsMicrobiologyCell biologyBiologyIn vitroGeneticsOrganic chemistryBiological systemLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsAntimicrobial Peptides and Activities