Preparation of macrocyclic musks via olefin metathesis: comparison with classical syntheses and recent advances
Adrian Sytniczuk, Mariusz Milewski, Anna Kajetanowicz, Karol Grela
Abstract
Recent advances in the synthesis of macrocycles with musk scent via catalytic olefin metathesis are presented with a particular emphasis on advantages offered by the metathesis technology. The review includes short historical background about musks and olefin metathesis to introduce the subject. Substantial emphasis is given on ring-closing metathesis (RCM) as a tool for the synthesis of cyclic compounds such as civetone, muscone, exaltolide, ambrettolide/isoambrettolide, and yuzu lactone. The bibliography includes 106 references.
Topics & Concepts
Olefin metathesisMetathesisChemistryRing-closing metathesisSalt metathesis reactionAcyclic diene metathesisCombinatorial chemistryOrganic chemistryPolymerizationPolymerSynthetic Organic Chemistry MethodsChemical Synthesis and AnalysisAdvanced Synthetic Organic Chemistry