Oxyresveratrol inhibits human colon cancer cell migration through regulating epithelial–mesenchymal transition and microRNA
Ting-Ann Lin, Weisheng Lin, Ya-Chun Chou, Kalyanam Nagabhushanam, Chi‐Tang Ho, Min‐Hsiung Pan
Abstract
Snail/E-cadherin expression. In addition, OXY improved EMT-related miRNA expression through, for example, lowering the levels of miR-3687 and miR-301a-3p while upregulating miR-3612 in TGF-β-induced HT-29 cells. In conclusion, OXY inhibits human colon cancer cell migration by regulating EMT and miRNAs. Based on these findings, it can be stated that OXY promotes anti-metastatic properties in CRC.
Topics & Concepts
Epithelial–mesenchymal transitionCell migrationMetastasisColorectal cancerCancer researchmicroRNACancerCancer cellTransforming growth factorMotilityCellMesenchymal stem cellCell growthChemistryMedicineInternal medicineBiologyCell biologyBiochemistryGeneCancer-related molecular mechanisms researchCancer Cells and MetastasisMicroRNA in disease regulation