Coculture of cancer cells with platelets increases their survival and metastasis by activating the TGFβ/Smad/PAI-1 and PI3K/AKT pathways
Haibo Tong, Koukou Li, Muya Zhou, Renfei Wu, Hongmei Yang, Peng Zheng, Qi Zhao, Kathy Qian Luo
Abstract
and Bad to elevate Bcl-2, which enhanced cell survival in circulation. Moreover, higher levels of PAI-1 were detected in metastatic tumors from melanoma and triple-negative breast cancer patients than in normal tissues, and high levels of PAI-1 were associated with a shorter overall survival time and worse disease progression in breast cancer. PAI-1 may act as a potential biomarker for detecting and treating metastatic tumor cells.
Topics & Concepts
Cancer researchMetastasisCancer cellCancerBiologyPI3K/AKT/mTOR pathwayBreast cancerMedicineImmunologyInternal medicineSignal transductionCell biologyInflammatory Biomarkers in Disease PrognosisLymphatic System and DiseasesAngiogenesis and VEGF in Cancer