PYTA: a universal chelator for advancing the theranostic palette of nuclear medicine
Megan E. Simms, Zhiyao Li, Megan M. Sibley, Alexander S. Ivanov, Caroline M. Lara, Timothy C. Johnstone, Vilmos Kertész, Amanda Fears, Frankie D. White, Daniel L.J. Thorek, Nikki A. Thiele
Abstract
PYTA is demonstrated to rapidly and stably complex 225 Ac, 177 Lu, 111 In, and 44 Sc, a “superfecta” of complementary but chemically distinct radiometals for targeted theranostic applications.
Topics & Concepts
Palette (painting)ChelationCancerNanotechnologyComputational biologyComputer scienceMedicineChemistryBiologyMaterials scienceInternal medicineOrganic chemistryOperating systemRadiopharmaceutical Chemistry and ApplicationsInorganic Chemistry and MaterialsMedical Imaging and Pathology Studies