PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1 mice
Zhuo Zhang, Xia Guo, Yan Liu, Pingyang Ke, Yuan Meng, Juan Gu, Li-Qin Hu, Ziwei Yuan, Ran Duan, Jing Luo, Fei Xiao
Topics & Concepts
Oxidative stressSOD1PKM2ApoptosisMitochondrionCell biologyOxidative phosphorylationChemistryReactive oxygen speciesGlycolysisBiologyMetabolismBiochemistrySuperoxide dismutasePyruvate kinaseEicosanoids and Hypertension PharmacologyCancer, Hypoxia, and MetabolismRedox biology and oxidative stress