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Hetero-aryl bromide precursor fluorine-18 radiosynthesis and preclinical evaluation of a novel positron emission tomography (PET) tracer [18F]GSK1482160

Guolong Huang, Xiaolei Lu, Yifan Qiu, Lei Bi, Peizhen Ye, Min Yang, Yanfang Shen, Hongjun Jin, Junbin Han

2022Bioorganic & Medicinal Chemistry20 citationsDOI

Topics & Concepts

RadiosynthesisChemistryBiodistributionRadioligandPositron emission tomographyIn vivoBromideEx vivoPurinergic receptorRadiochemistryPet imagingTranslocator proteinBlood–brain barrierNuclear medicineIn vitroExtracellularBiochemistryMicrogliaCentral nervous systemInternal medicineInflammationOrganic chemistryBiologyMedicineBiotechnologyAdenosine and Purinergic SignalingSynthesis and Biological EvaluationPharmacological Receptor Mechanisms and Effects
Hetero-aryl bromide precursor fluorine-18 radiosynthesis and preclinical evaluation of a novel positron emission tomography (PET) tracer [18F]GSK1482160 | Litcius