<i>In vitro</i> and <i>in vivo</i> evaluation of liposomes modified with polypeptides and red cell membrane as a novel drug delivery system for myocardium targeting
Xueyan Liu, Liangke Zhang, Wengao Jiang, Zhangyou Yang, Zongjie Gan, Chao Yu, Ran Tao, Huali Chen
Abstract
, liposomes were intravenously injected into mice, and the blood and organs were collectedat different times to analyze the pharmacokinetics profile of liposomes. The cellular uptake and intracellular distribution of liposomes of different composition into MCs demonstrated that RCM-modified liposomes had the best delivery capability. The pharmacokinetics study further demonstrated that RCM-modified liposomes had prolonged mean residence time (MRT) and more accumulation in the heart. This study indicated that RCM can be used to modify liposomes in combination with polypeptides, because such modification increases the myocardial targeting of liposomes. Therefore, this system constructed in this study might be a potentially effective myocardial drug delivery system.