Exercise as a Moderator of Persistent Neuroendocrine Symptoms of COVID-19
Candida J. Rebello, Christopher L. Axelrod, Charles F. Reynolds, Frank L. Greenway, John P. Kirwan
Abstract
Precipitated by chronic psychological stress, immune system dysregulation, and a hyperinflammatory state, the sequelae of postacute COVID-19 (long COVID) include depression and new-onset diabetes. We hypothesize that exercise counters the neuropsychiatric and endocrine sequelae of long COVID by inducing the release of circulating factors that mediate the anti-inflammatory response, support brain homeostasis, and increase insulin sensitivity.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Immune systemDepression (economics)MedicineEndocrine systemHomeostasisDiabetes mellitusModerationInsulin sensitivityChronic stress2019-20 coronavirus outbreakNeurosciencePsychologyInternal medicineImmunologyEndocrinologyInsulin resistanceHormoneDiseaseVirologySocial psychologyEconomicsMacroeconomicsInfectious disease (medical specialty)OutbreakLong-Term Effects of COVID-19Tryptophan and brain disordersInflammasome and immune disorders