Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand
Parasvi S. Patel, Arash Algouneh, Razqallah Hakem
Topics & Concepts
Synthetic lethalityBiologyDNA repairPolymeraseCancer researchFanconi anemiaPARP1Protein-fragment complementation assayGeneticsPhenotypeGenePoly ADP ribose polymeraseComplementationPARP inhibition in cancer therapyCRISPR and Genetic EngineeringDNA Repair Mechanisms