A hetero-bimetallic Ru(<scp>ii</scp>)–Ir(<scp>iii</scp>) photosensitizer for effective cancer photodynamic therapy under hypoxia
Mengsi Zheng, Xinlin Lin, Kai Xiong, Xiting Zhang, Yu Chen, Liang‐Nian Ji, Hui Chao
Abstract
A hetero-bimetallic Ru(II)-Ir(III) photosensitizer was developed. Upon light exposure, contrary to the homogeneous Ru(II)-Ru(II) and Ir(III)-Ir(III) complexes that can only produce singlet oxygen, Ru(II)-Ir(III) can generate multiple reactive oxygen species and kill hypoxic tumors. This study presents the first example of a hetero-bimetallic type-I and type-II dual photosensitizer.
Topics & Concepts
Bimetallic stripPhotodynamic therapyPhotosensitizerChemistryCancer therapyCatalysisCancerPhotochemistryMedicineBiochemistryOrganic chemistryInternal medicineNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisPhotodynamic Therapy Research Studies