Gallium Nitrate Enhances Antimicrobial Activity of Colistin against Klebsiella pneumoniae by Inducing Reactive Oxygen Species Accumulation
Mingjuan Guo, Ping Tian, Qingqing Li, Bao Meng, Yuting Ding, Yanyan Liu, Yasheng Li, Liang Yu, Jiabin Li
Abstract
. Our results suggest that by combining GaNt with colistin, antioxidant activity was suppressed and reactive oxygen species accumulation was induced in bacterial cells, enhancing antimicrobial activity against K. pneumoniae. We found that GaNt functioned as an antibiotic adjuvant when combined with colistin by inhibiting the growth of multidrug-resistant K. pneumoniae. Our study provides insight into the use of an adjuvant to boost the antibiotic potential of colistin for treating infections caused by multidrug-resistant K. pneumoniae.
Topics & Concepts
ColistinKlebsiella pneumoniaeAntimicrobialMicrobiologyPolymyxinIn vivoAcinetobacter baumanniiBiologyPharmacologyPseudomonas aeruginosaChemistryBacteriaEscherichia coliAntibioticsBiochemistryBiotechnologyGeneGeneticsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyBacterial Identification and Susceptibility Testing